MYRIOCIN
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1.What is the MYRIOCIN ?
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.[Cayman Chemical]
2.What is the CAS number for MYRIOCIN ?
The CAS number of MYRIOCIN is 35891-70-4.
More information of MYRIOCIN 35891-70-4 are:
|
CAS?Number |
35891-70-4 |
|
Density |
1.123 g/cm3 |
|
Melting Point |
170-172℃ |
|
Boiling Point |
636.7 °C at 760 mmHg |
|
Flash Point |
338.8 °C |
|
Vapor Pressure |
6.88E-19mmHg at 25°C |
|
Refractive Index |
1.521 |
|
HS CODE |
29225090 |
|
PSA |
141.08000 |
|
LogP |
3.00930 |
|
Pka |
1.79±0.50(Predicted) |
3.What is the molecular formula of MYRIOCIN ?
The chemical formula of?MYRIOCIN is C21 H39 NO6 which containing 21 Carbon atoms,39 Hydrogen atoms,1 Nitrogen atoms and 6 Oxygen atoms,and the molecular weight, and the molecular weight of MYRIOCIN is 401.544
4.What is MYRIOCIN(35891-70-4)used for?
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.
InChI:InChI=1/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m0/s1
Relevant articles related to MYRIOCIN:
|
Article |
Source |
|
Construction of Quaternary Carbon Stereocenter of α-Tertiary Amine through Remote C-H Functionalization of Tris Derivatives: Enantioselective Total Synthesis of Myriocin |
Miyagawa, Takashi,Inuki, Shinsuke,Oishi, Shinya,Ohno, Hiroaki , p. 5485 - 5490 (2019) |
5.Buy Good Quality MYRIOCIN 35891-70-4 with a minimum purity of 99%
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