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1.What is the Trimethylsilylacetylene ?

Trimethylsilylacetylene (TMSA), also known as ethynyltrimethylsilane, is a versatile reagent widely used in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira coupling) to introduce alkyne functionalities. It serves as a key building block in the preparation of conjugated dendrons, alkyne-dicobaltcarbonyl complexes, rhodium complexes, and supramolecular oligo-phenylene-ethynylene systems. Its trimethylsilyl group acts as a protective moiety, enabling selective deprotection for further functionalization. TMSA is also employed in zirconium-mediated reactions and GaCl3-promoted ethenylations, demonstrating its utility in stereoselective transformations and the synthesis of sterically hindered compounds. Its applications span nonlinear optics, molecular wires, and catalytic systems.

Trimethylsilylacetylene is a valuable reagent used in ethynylation by palladium(0)-catalyzed coupling/condensation with aryl and vinyl halides and triflates, or by nucleophilic attack of the corresponding acetylide on electrophilic centers; reacts with alkyl iodides, tin hydrides,6 and dichloroketene in a regioselective and stereoselective manner, participating in the following synthesis reactions: Ethynylations, Palladium(0)-Catalyzed Coupling Reactions,Reaction of Trimethylsilylacetylides with Electrophiles, Radical-Initiated and Transition Metal-Catalyzed Additions, Cycloaddition Reactions, Ethynylations, Cycloaddition Reactions, Further Transformations etc.

2.What is the CAS number for Trimethylsilylacetylene ?

The CAS number of Trimethylsilylacetylene is 1066-54-2.

More information of Trimethylsilylacetylene 1066-54-2 are:

3.What is the molecular formula of Trimethylsilylacetylene ?

The chemical formula of?Trimethylsilylacetylene is C5H10Si which containing 5 Carbon atoms,10 Hydrogen atoms and 1 Silicon atoms,and the molecular weight, and the molecular weight of Trimethylsilylacetylene is 98.2199

4.What is Trimethylsilylacetylene(1066-54-2)used for?

Trimethylsilylacetylene (TMSA), also known as ethynyltrimethylsilane, is a versatile reagent widely used in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira coupling) to introduce alkyne functionalities. It serves as a key building block in the preparation of conjugated dendrons, alkyne-dicobaltcarbonyl complexes, rhodium complexes, and supramolecular oligo-phenylene-ethynylene systems. Its trimethylsilyl group acts as a protective moiety, enabling selective deprotection for further functionalization. TMSA is also employed in zirconium-mediated reactions and GaCl3-promoted ethenylations, demonstrating its utility in stereoselective transformations and the synthesis of sterically hindered compounds. Its applications span nonlinear optics, molecular wires, and catalytic systems.

InChI:InChI=1/C5H10Si/c1-5-6(2,3)4/h1H,2-4H3

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5.Reputable factory supply Trimethylsilylacetylene 1066-54-2 in bulk at low price

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