Ebselen

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What is the Ebselen ?

Ebselen is yellow to beige crystalline powder, while it's Molecular Formula is C13H9NOSe. Ebselen is a lipid-soluble organoselenium compound. Numerous in vivo experiments have demonstrated that ebselen is able to inhibit both vasospasm and tissue damage in cerebral stroke/ischemia animal models (i.e. rat, mice, guinea pig and dog).For example, ebselen has been shown to provide significant protection against ischemic damage in both gray and white matter, and in the ventral posterior nucleus of rodent brains.Additionally, administration of ebselen in gerbils significantly reduces neuronal death induced by ischemia and reperfusion in the hippocampal CA1 region.It has been reported that ebselen inhibits inositol monophosphatase and acts as a safe treatment for bipolar disorder. The optimal GPx-like activity of ebselen was observed at neutral or nearphysiological pH (7.4), and the activity of ebselen was barely detected in acidic medium.During ischemia, brain pH falls rapidly within the first 5 min from 7.0 to 6.2, which is not optimal for ebselen's GPx-like activity.Meanwhile, since ebselen has shown promising activity in the treatment of stroke, it seems that GPx-like activity of ebselen in the brain may not occur.Thus, the enzymatic reduction of ebselen by TrxR might be the main contribution to its antioxidant property during ischemia. Unlike inorganic and aliphatic selenium compounds, ebselen does not liberate the selenium moiety, which remains within the ring structure. Subsequent metabolism involves methylation, glucuronidation and hydroxylation. Additionally, ebselen could also inhibit enzymes such as lipoxygenases, nitric oxide synthases, nitrogen oxides, protein kinase C and H1/K1-ATPase. Besides the relationship with redox systems, another neuroprotective mechanism of ebselen is involved in controlling the expression of gaminobutyric acid shunt enzymes to supply the tricarboxylic acid cycle, and significantly inhibiting acetylcholinesterase activity,demonstrating its engagement in the metabolic system.

What is the CAS number for Ebselen ?

The CAS number of Ebselen is 60940-34-3.

More information of Ebselen 60940-34-3 are:

Synonyms	2-Phenyl-1,2-benzisoselenazol-3(2H)-one;2-Phenyl-1,2-benzoisoselenazol-3(2H)-one;Ebselen;Lopac E 3520;NSC 639762;PZ51;2-phenyl-1,2-benzoselenazol-3(2H)-one;1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-;2-Phenyl-1,2-benzoselenazol-3(2H)-one;
CAS?Number	60940-34-3
Molecular Formula	C13H9NOSe
Molecular Weight	274.181
Melting Point	178-181 °C
Boiling Point	402.8 °C at 760 mmHg
Flash Point	197.4 °C
HS CODE	29310099
PSA	22.00000
LogP	2.04770
Pka	-0.40±0.20(Predicted)

What is Ebselen (60940-34-3) used for?

Ebselen is one of the selenium-containing anti-inflammatory drugs.In 2003, Rocha and co-workers identified diselenides as a new class of antiinflammatory agents.In 2014, Nogueira and co-workers reported the synthesis and anti-inflammatory activity of salicyclic-based diselenides and selenocynates.Recently, Wilhelm and co-workers identified 4-phenylselenyl-7-chloroquinoline 270 as a potent antiinflammatory compound.

InChI:InChI=1/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H

Articles related to Ebselen:

Article

Source

Thermal and Photoinduced Copper-Promoted C-Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis

Thanna, Sandeep,Goins, Christopher M.,Knudson, Susan E.,Slayden, Richard A.,Ronning, Donald R.,Sucheck, Steven J.

, p. 3844 - 3854 (2017)

Synthesis of Benzoisoselenazolones via Rh(III)-Catalyzed Direct Annulative Selenation by Using Elemental Selenium

Xu-Xu, Qing-Feng,Nishii, Yuji,Uetake, Yuta,Sakurai, Hidehiro,Miura, Masahiro

supporting information, p. 17952 - 17959 (2021/11/16)

How to get the best price on Ebselen?

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