What is the 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone?

1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone is , while it's Molecular Formula is C15H8BrClF2O. Used in Organic Synthesis: 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a key intermediate in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide range of complex organic molecules. Used in Pharmaceutical Research: In the pharmaceutical industry, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a precursor in the development of new drugs. Its unique structure allows for selective functionalization, which is crucial for the synthesis of bioactive compounds with potential therapeutic applications. Used as a Reagent in Chemical Reactions: 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone serves as a reagent in a variety of chemical reactions, including those that require the introduction of specific functional groups or the formation of new chemical bonds, contributing to the advancement of chemical research and the discovery of novel chemical entities. Used in the Synthesis of Complex Organic Molecules: Due to its specific structural features, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a valuable building block in the synthesis of complex organic molecules, enabling chemists to construct intricate molecular architectures with potential applications in various fields.

What is 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone (1378387-81-5) used for?

1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is a complex organic compound characterized by a fluorene ring with a bromine and two fluorine atoms at the 7 and 9 positions, respectively. A chloroethanone group is attached to the fluorene ring, endowing this molecule with unique structural and reactivity properties. It is a versatile building block in organic synthesis and pharmaceutical research, valued for its potential in the development of innovative drugs and materials.

What is the 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone?

1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone is , while it's Molecular Formula is C15H8BrClF2O. Used in Organic Synthesis: 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a key intermediate in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide range of complex organic molecules. Used in Pharmaceutical Research: In the pharmaceutical industry, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a precursor in the development of new drugs. Its unique structure allows for selective functionalization, which is crucial for the synthesis of bioactive compounds with potential therapeutic applications. Used as a Reagent in Chemical Reactions: 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone serves as a reagent in a variety of chemical reactions, including those that require the introduction of specific functional groups or the formation of new chemical bonds, contributing to the advancement of chemical research and the discovery of novel chemical entities. Used in the Synthesis of Complex Organic Molecules: Due to its specific structural features, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a valuable building block in the synthesis of complex organic molecules, enabling chemists to construct intricate molecular architectures with potential applications in various fields.

What is 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone (1378387-81-5) used for?

1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is a complex organic compound characterized by a fluorene ring with a bromine and two fluorine atoms at the 7 and 9 positions, respectively. A chloroethanone group is attached to the fluorene ring, endowing this molecule with unique structural and reactivity properties. It is a versatile building block in organic synthesis and pharmaceutical research, valued for its potential in the development of innovative drugs and materials.

1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone

Q: What is the CAS number for 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone?

The CAS number of 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone is 1378387-81-5.

1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone GMP Manufacturer Global Trade 1378387-81-5 with Fast Delivery

Molecular Formula: C15H8BrClF2O
Molecular Weight: 357.5772264
Melting Point: 183.0 to 187.0 °C
Boiling Point: 428.5±45.0 °C(Predicted)
PSA： 17.07000
Density: 1.69±0.1 g/cm3(Predicted)
LogP: 4.99110

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1378387-81-5 Process route

: 67442-07-3
2-chloro-N-methoxy-N-methylacetamide

: 2-bromo-9,9-difluoro-7-iodo-9H-fluorene

: 1378387-81-5
1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone

Conditions

Conditions	Yield
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -15 - -5 ℃; for 1h; Inert atmosphere; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; at -5 - 0 ℃; Inert atmosphere;	76%
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 20 ℃; for 1h; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; toluene; for 1h; Reagent/catalyst; Solvent; Temperature;	74%
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 0 ℃; for 0.5h; Inert atmosphere; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; tert-butyl methyl ether; at -10 - 0 ℃; for 2h;	70.8%
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 0 ℃; for 0.5h; Inert atmosphere; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; tert-butyl methyl ether; at -10 - 0 ℃; for 2h;	70.8%
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 0.45h; Cooling with ice; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1.7h;	15%
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; for 0.533333h; Inert atmosphere; Cooling with ice; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; toluene; for 4h; Inert atmosphere;	1.51 g
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -12 ℃; for 1h; Inert atmosphere; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; tert-butyl methyl ether; at -10 - 0 ℃; for 2h; Temperature; Inert atmosphere;
2-bromo-9,9-difluoro-7-iodo-9H-fluorene; With isopropylmagnesium chloride; In tetrahydrofuran; at -12 ℃; for 1h; Inert atmosphere; 2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; tert-butyl methyl ether; at -10 - 0 ℃; for 2h; Temperature;

: C₁₇H₁₂BrClF₂O₂

: 1378387-81-5
1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone

Conditions

Conditions	Yield
With perchloric acid; In dichloromethane; at 40 ℃; for 6h; Reagent/catalyst; Temperature;	90.4%

1378387-81-5 Upstream products

1133-80-8
2-bromo-9H-fluorene
123348-27-6
2-bromo-7-iodofluorene
67442-07-3
2-chloro-N-methoxy-N-methylacetamide
3096-56-8
2-bromofluoren-9-one

1378387-81-5 Downstream products

1499193-61-1
(S)-6-(2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl) 5-tert-butyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate
1256393-27-7
3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester
1256388-49-4
6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester
1256388-48-3
5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester