5-[[4-(dimethylamino)phenyl]methylene]barbituric acid

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5-[[4-(dimethylamino)phenyl]methylene]barbituric acid Good Supplier In Bulk Supply High Purity 1753-47-5

  • Molecular Formula: C13H13 N3 O3
  • Molecular Weight: 259.265
  • PSA： 78.51000 
  • Density: 1.337g/cm3 
  • LogP: 1.15960 

5-[[4-(dimethylamino)phenyl]methylene]barbituric acid(Cas 1753-47-5) Usage

General Description

5-[[4-(dimethylamino)phenyl]methylene]barbituric acid, also known as methylene blue, is a synthetic organic compound with a wide range of applications. It is a deep blue dye that is commonly used as a staining agent in biological research and as a diagnostic marker for various medical tests. Methylene blue has also been found to have therapeutic properties, and is used in the treatment of methemoglobinemia, a condition where the blood cannot carry sufficient oxygen to the body's tissues. It has also shown potential as a treatment for neurological disorders, such as Alzheimer's disease and Parkinson's disease, and is being investigated for its anti-cancer properties. Additionally, methylene blue has been used as an antimicrobial agent, particularly in the treatment of urinary tract infections. Its versatility and potential therapeutic applications make it an important compound in the fields of medicine and chemistry.

InChI:InChI=1/C13H13N3O3/c1-16(2)9-5-3-8(4-6-9)7-10-11(17)14-13(19)15-12(10)18/h3-7H,1-2H3,(H2,14,15,17,18,19)

1753-47-5 Relevant articles

Succinimidinium hydrogensulfate ([H-Suc]HSO4) as an efficient ionic liquid catalyst for the synthesis of 5-arylidenepyrimidine-2,4,6(1H,3H,5H)-trione and pyrano-pyrimidinones derivatives

Goli-Jolodar, Omid,Shirini, Farhad,Seddighi, Mohadeseh

, p. 457 - 463 (2016)

In this work, succinimidinium hydrogensu...

1-n-butyl-3-methylimmidazolium tetrafluoroborate-promoted green synthesis of 5-arylidene barbituric acids and thiobarbituric acid derivatives

Wang, Chun,Ma, Jing-Jun,Zhou, Xin,Zang, Xiao-Huan,Wang, Zhi,Gao, Yong-Jun,Cui, Peng-Lei

, p. 2759 - 2764 (2005)

The room temperature ionic liquid 1-n-bu...

A simple method for knoevenagel condensation of α,β-conjugated and aromatic aldehydes with barbituric acid

Jursic

, p. 655 - 657 (2001)

Several aromatic and α,β-conjugated arom...

CoFe2O4 nanoparticles: An efficient heterogeneous magnetically separable catalyst for "click" synthesis of arylidene barbituric acid derivatives at room temperature

Rajput, Jaspreet Kaur,Kaur, Gagandeep

, p. 1697 - 1704 (2013)

A coprecipitation method was used to syn...

Preparation of benzylidene barbituric acids promoted by infrared irradiation in absence of solvent

Alcerreca, Guadalupe,Sanabria, Ruben,Miranda, Rene,Arroyo, Gabriel,Tamariz, Joaquin,Delgado, Francisco

, p. 1295 - 1301 (2000)

Several benzaldehydes were condensed wit...

Organic reactions in ionic liquids: Ionic liquid promoted Knoevenagel condensation of aromatic aldehydes with (2-thio)barbituric acid

Hu, Yi,Chen, Zhen-Chu,Le, Zhang-Gao,Zheng, Qin-Guo

, p. 4521 - 4529 (2004)

The Knoevenagel condensation of aromatic...

Synthesis and Antimycobacterial Activity of 5-(Arylmethylene)Hexahydropyrimidine-2,4,6-Triones

Luzhnova,Tyrkov,Gabitova

, p. 810 - 812 (2016)

A series of 5-(arylmethylene)hexahydropy...

The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

Zhou, Kaixiang,Fu, Hualong,Feng, Liang,Cui, Mengchao,Dai, Jiapei,Liu, Boli

, p. 11665 - 11668 (2015)

A new array of near-infrared probes cont...

SiO2?12WO3?24H2O: A highly efficient catalyst for the synthesis of 5-arylidene barbituric acid in the presence of water

Li, Ji-Tai,Sun, Ming-Xuan

, p. 353 - 355 (2009)

The condensation of aromatic aldehydes a...

Assessing the potential of para-donor and para-acceptor substituted 5-benzylidenebarbituric acid derivatives as push–pull electronic systems: Experimental and quantum chemical study

Stojiljkovi?, Ivana N.,Ran?i?, Milica P.,Marinkovi?, Aleksandar D.,Cvijeti?, Ilija N.,Mil?i?, Milo? K.

, (2021)

Electronic interactions in donor-π-linke...

Structurally simple D–A-type organic sensitizers for dye-sensitized solar cells: effect of anchoring moieties on the cell performance

Naik, Praveen,Su, Rui,Babu, Dickson D.,El-Shafei, Ahmed,Adhikari, Airody Vasudeva

, p. 2457 - 2466 (2017)

Abstract: In this work, we report synthe...

Preparation of 5,5′-pyrilidene and 5,5′-quinolidene bis-barbituric acid derivatives

Jursic, Branko S.,Neumann, Donna M.

, p. 465 - 474 (2003)

NMR reaction following experiments were ...

A study on the physical properties of low melting mixtures and their use as catalysts/solvent in the synthesis of barbiturates

Theresa, Letcy Vincent,Avudaiappan, Govindan,Shaibuna, Machingal,Hiba, Kottayil,Sreekumar, Krishnapillai

, p. 1849 - 1860 (2021/06/17)

In recent years, deep eutectic solvents ...

Barbituric acid based fluorogens: Synthesis, aggregation-induced emission, and protein fibril detection

Ding, Siyang,Yao, Bicheng,Schobben, Louis,Hong, Yuning

, (2020/01/11)

Fluorescent dyes, especially those emitt...

Verjuice as a green and bio-degradable solvent/catalyst for facile and eco-friendly synthesis of 5-arylmethylenepyrimidine-2,4,6-trione, pyrano[2,3-d]pyrimidinone and pyrimido[4,5-d]pyrimidinone derivatives

Safari, Niloufar,Shirini, Farhad,Tajik, Hassan

, p. 887 - 897 (2019/03/27)

Verjuice (unripe grape juice), a natural...

1753-47-5 Process route

N-{(1E)-[4-(dimethylamino)phenyl]methylidene}benzenemethanamine
24431-17-2

N-{(1E)-[4-(dimethylamino)phenyl]methylidene}benzenemethanamine

5-(4-chlorobenzylidene)barbituric acid
27402-31-9

5-(4-chlorobenzylidene)barbituric acid

4-chlorobenzaldehyde hydrate

4-chlorobenzaldehyde hydrate

5-(4-dimethylaminobenzylidene)barbituric acid
1753-47-5

5-(4-dimethylaminobenzylidene)barbituric acid

N-[(1E)-(4-chlorophenyl)methylidene]benzenemethanamine
130517-96-3

N-[(1E)-(4-chlorophenyl)methylidene]benzenemethanamine

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

Conditions
Conditions Yield
In dimethylsulfoxide-d6; water-d2; at 60 ℃; for 20h;
5-(4-methoxybenzylidene)barbituric acid
49546-71-6

5-(4-methoxybenzylidene)barbituric acid

N-{(1E)-[4-(dimethylamino)phenyl]methylidene}benzenemethanamine
24431-17-2

N-{(1E)-[4-(dimethylamino)phenyl]methylidene}benzenemethanamine

4-methoxybenzaldehyde hydrate

4-methoxybenzaldehyde hydrate

5-(4-dimethylaminobenzylidene)barbituric acid
1753-47-5

5-(4-dimethylaminobenzylidene)barbituric acid

(E)-N-benzyl-1-(4-methoxyphenyl)methanimine
130517-94-1

(E)-N-benzyl-1-(4-methoxyphenyl)methanimine

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

Conditions
Conditions Yield
In dimethylsulfoxide-d6; water-d2; at 60 ℃; for 1h;

1753-47-5 Upstream products

  • 67-52-7
    67-52-7

    BARBITURIC ACID

  • 100-10-7
    100-10-7

    4-dimethylamino-benzaldehyde

  • 889-37-2
    889-37-2

    N,N-dimethyl-4-((phenylimino)methyl)aniline

  • 130517-96-3
    130517-96-3

    N-[(1E)-(4-chlorophenyl)methylidene]benzenemethanamine

1753-47-5 Downstream products

  • 23450-59-1
    23450-59-1

    5-(4-(dimethylamino)benzylidene)barbituric acid

  • 104-88-1
    104-88-1

    4-chlorobenzaldehyde

  • 24431-17-2
    24431-17-2

    N-{(1E)-[4-(dimethylamino)phenyl]methylidene}benzenemethanamine

  • 100-10-7
    100-10-7

    4-dimethylamino-benzaldehyde

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