What is the (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid?

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid is , while it's Molecular Formula is C27H46O5. 3a,7a,12a-Trihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3a,7a,12a-Trihydroxycoprostanic Acid.

What is the CAS number for (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid?

The CAS number of (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid is 547-98-8.

What is the (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid?

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid is , while it's Molecular Formula is C27H46O5. 3α,7α,12α-Trihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α,12α-Trihydroxycoprostanic Acid.

What is the CAS number for (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid?

The CAS number of (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid is 547-98-8.

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid 547-98-8 with purity >99% Low price in stock

Molecular Formula: C27H46O5
Molecular Weight: 450.659
Vapor Pressure: 7.56E-08mmHg at 25°C
Boiling Point: 409.4°C at 760 mmHg
Flash Point: 215.5°C
PSA： 97.99000
Density: 1.134g/cm³
LogP: 4.47490

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid(Cas 547-98-8) Usage

Definition	ChEBI: A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions.
General Description	Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.
Biochem/physiol Actions	Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

InChI:InChI=1/C10H16O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h5,7H,1-4,6,8H2,(H,11,12)(H,13,14)

547-98-8 Relevant articles

A convenient synthesis of 5β-cholestan-26-oic and 5β-cholestan-26,27-dioic acids

Starchenkov,Trapencieris,Kauss,Jas,Kalvinsh

, p. 143 - 147 (2007/10/03)

A new method for the preparation of 5β-c...

Partial synthesis of 25D- and 25L-cholestanoic acids from some common bile acids.

Briggs

, p. 1431 - 1434 (2007/10/15)

Synthesis and metabolism of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al. Bile acids and steroids 161.

Okuda,Danielsson

, p. 2160 - 2165 (2007/10/21)

547-98-8 Process route

: 264128-73-6
3α,7α,12α-trihydroxy-25-carboxy-5β-cholestan-26-oic acid

: 547-98-8
Trihydroxycholestanoic acid

Conditions

Conditions	Yield
With lithium chloride; In dimethyl sulfoxide; at 160 ℃; for 1h;	60%

: 5226-26-6
3α,7α,12α-Trihydroxy-5β-cholesten-24-26-saeure

: 547-98-8
Trihydroxycholestanoic acid

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide; In acetic acid;

547-98-8 Upstream products

5226-26-6
3α,7α,12α-Trihydroxy-5β-cholesten-24-26-saeure
264128-73-6
3α,7α,12α-trihydroxy-25-carboxy-5β-cholestan-26-oic acid
2097-89-4
cholic acid triformate
96736-29-7
3α,7α,12α-triformyloxy-5β-24-hydroxy-cholane

547-98-8 Downstream products

81-25-4
cholic acid
17974-66-2
(25RS)-3α,7α-dihydroxy-5β-cholestan-26-oic acid
141417-49-4
methyl 3α,7α-diacetoxy-12-oxo-5β-cholestan-26-oate-12-tosylhydrazone