Top Quality Chinese Factory supply 154026-93-4 tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate

Q: What is the tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate?

tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate is , while it's Molecular Formula is C10H19ClO4. (3R,5S)-6-Chloro-3,5-dihydroxyhexanoic Acid tert-Butyl Ester is an intermediate in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor.

Quality products?make an important contribution to long-term revenue and profitability. Top Quality Chinese Factory supply 154026-93-4 tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate

1.What is the tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate ?

(3R,5S)-6-Chloro-3,5-dihydroxyhexanoic Acid tert-Butyl Ester is an intermediate in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor.

: 276249-18-4
tert-butyl 6-chloro-3,5-dioxohexanoate

: 154026-93-4
1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate

Conditions

Conditions	Yield
With hydrogen; (R)-[RuCl₂(BINAP)]n; In ethanol; at 95 - 105 ℃; for 0.666667 - 480h; under 67506.8 - 75007.5 Torr; Conversion of starting material;	95%
With hydrogen; (R)-(6,6′-dimethoxy-[1,1′-biphenyl]-2,2′-diyl)bis(diphenylphosphine); In ethanol; at 20 ℃; for 7h; under 750.075 Torr; Temperature; Pressure; Catalytic behavior; Autoclave;	95.5%
Multi-step reaction with 2 steps 1: 72 percent / NADPH; recBADH 2: Me₄N[B(OAc)3H] / acetonitrile; acetic acid / 5 h / -25 °C With recBADH; NADPH; tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; 2: Evans' (anti-selective) reduction;

: 154026-92-3
Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate

: 154026-93-4
1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate

Conditions

Conditions	Yield
With carbonyl reductase Phe₁₄₅Tyr/Thr₁₅₂Ser mutant; NADPH; In aq. phosphate buffer; isopropyl alcohol; at 30 ℃; for 8h; pH=7; Reagent/catalyst; Kinetics; Enzymatic reaction;	99%
With D-glucose; at 30 ℃; for 8h; pH=7; Reagent/catalyst; Enzymatic reaction;	95.1%
Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -70 ℃; for 0.333333h; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -70 ℃; for 3h; With dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; pH=9; Further stages.;	12.8 g
Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate; With diethyl methoxy borane; In tetrahydrofuran; methanol; at 25 ℃; for 1h; Inert atmosphere; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; for 4h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;	17 g
With glucose dehydrogenase; alpha-D-glucopyranose; BgADH₅ enzyme; nicotinamide adenine dinucleotide phosphate; In water; at 30 ℃; pH=6.5; Reagent/catalyst; diastereoselective reaction; Enzymatic reaction;	97 % de
With sodium tetrahydroborate; water; sodium docusate; at 0 ℃; for 14h; diastereoselective reaction;
With sodium tetrahydroborate; In tetrahydrofuran; at -40 - 30 ℃; for 6h; Inert atmosphere;	6.4 g
With Klebsiella oxytoca alcohol dehydrogenase overexpressed in Escherichia coli Rosetta (DE₃); NADPH; NADH; In aq. buffer; at 30 ℃; for 24h; stereoselective reaction; Enzymatic reaction;	> 99.5 % de
With aldo-keto reductase from thermotolerant yeast Kluyveromyces marxianus ZJB₁₄₀₅₆ mutant with W₂₉₇H/Y₂₉₆W/K₂₉H; NADPH; In aq. phosphate buffer; at 35 ℃; pH=7; stereoselective reaction; Enzymatic reaction;	> 99.5 % de

2.What is the CAS number for tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate ?

The CAS number of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate is 154026-93-4.

More information of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate 154026-93-4 are:

CAS?Number	154026-93-4
Density	1.169 g/cm³
Boiling Point	364.584 °C at 760 mmHg
Flash Point	174.295 °C
Vapor Pressure	0mmHg at 25°C
Refractive Index	1.479
PSA	66.76000
LogP	1.06890
Pka	13.69±0.20(Predicted)

3.What are another words for tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate ?

Synonyms?for?tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate 154026-93-4:tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate;

4.What is the molecular formula of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate?

The chemical formula of ?tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate is?C10H19ClO4 which containing 10 Carbon atoms,19 Hydrogen atoms,1 Chlorine atoms and 4 Oxygen atoms,and the molecular weight of??tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate?is 238.711.

5.What is tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate (154026-93-4) used for?

tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate is an organic compound that serves as a crucial intermediate in the synthesis of pharmaceuticals. It is characterized by its specific stereochemistry and functional groups, which play a vital role in its applications.

InChI:InChI=1/C10H19ClO4/c1-10(2,3)15-9(14)5-7(12)4-8(13)6-11/h7-8,12-13H,4-6H2,1-3H3/t7-,8+/m1/s1

Relevant articles related to tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate:

Article

Source

Directed Evolution of Carbonyl Reductase from Rhodosporidium toruloides and Its Application in Stereoselective Synthesis of tert-Butyl (3R,5S)-6-Chloro-3,5-dihydroxyhexanoate

Liu, Zhi-Qiang,Wu, Lin,Zhang, Xiao-Jian,Xue, Ya-Ping,Zheng, Yu-Guo

, p. 3721 - 3729 (2017)

Enzymatic preparation of optically pure t-butyl 6-chloro-(3R,5S)-dihydroxyhexanoate by a novel alcohol dehydrogenase discovered from Klebsiella oxytoca

Xu, Tingting,Wang, Can,Zhu, Shaozhou,Zheng, Guojun

, p. 72 - 79 (2017/05/24)

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