10-Hydroxy-2-decenoic acid
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1.What is the 10-Hydroxy-2-decenoic acid ?
10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.
Used in Pharmaceutical Industry:
10-Hydroxy-2-decenoic acid is used as a therapeutic agent for promoting longevity, particularly in the model organism C. elegans, at a concentration of 25 μM. Its ability to down-regulate matrix metalloproteinases (MMPs) makes it a potential treatment for rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM.
Used in Angiogenesis Inhibition:
In the field of cancer research, 10-HDA is used as an inhibitor of VEGF-induced angiogenesis in HUVECs at a concentration of 500 μM, which could have implications for the development of anti-cancer therapies.
Used in Neurological Applications:
10-Hydroxy-2-decenoic acid is used as a neurodifferentiation agent to facilitate the differentiation of neurons from neural stem/progenitor cells at a concentration of 100 μM, which may contribute to the development of treatments for neurological disorders.
Used in Dermatological Applications:
In the cosmetic and skincare industry, 10-HDA is used as a skin rejuvenation agent to promote collagen production by skin fibroblasts at a concentration of 1.5 mM, potentially leading to improved skin health and appearance.
Used in Nutritional Supplements:
Given its presence in royal jelly and its various health-promoting properties, 10-HDA can be used as an ingredient in nutritional supplements to support overall health and well-being.
2.What is the CAS number for 10-Hydroxy-2-decenoic acid ?
The CAS number of 10-Hydroxy-2-decenoic acid is 14113-05-4.
More information of 10-Hydroxy-2-decenoic acid 14113-05-4 are:
|
CAS?Number |
14113-05-4 |
|
Density |
1.038 g/cm3 |
|
Melting Point |
64.0 to 68.0 °C |
|
Boiling Point |
339.2 °C at 760 mmHg |
|
Flash Point |
173.1 °C |
|
Vapor Pressure |
6.5E-06mmHg at 25°C |
|
Refractive Index |
1.465 |
|
HS CODE |
29181990 |
|
PSA |
57.53000 |
|
LogP |
1.96010 |
|
Pka |
4.78±0.10(Predicted) |
3.What is the molecular formula of 10-Hydroxy-2-decenoic acid ?
The chemical formula of?10-Hydroxy-2-decenoic acid is C10H18O3 which containing 10 Carbon atoms,18 Hydrogen atoms and 3 Oxygen atoms,and the molecular weight, and the molecular weight of 10-Hydroxy-2-decenoic acid is 186.251
4.What is 10-Hydroxy-2-decenoic acid(14113-05-4)used for?
10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.
InChI:InChI=1/C11H22O3/c1-10(11(13)14)8-6-4-2-3-5-7-9-12/h10,12H,2-9H2,1H3,(H,13,14)
Relevant articles related to 10-Hydroxy-2-decenoic acid:
|
Article |
Source |
|
A new approach to the synthesis of royal jelly acid |
Zong, Qian-Shou,Wu, Jian-Yi , p. 399 - 401 (2014) |
|
LA REACTION DE WITTIG-HORNER EN MILIEU HETEROGENE VI. SELECTIVITE DE LA REACTION SUR DES COMPOSES BIFONCTIONNELS |
Villieras, Jean,Rambaud, Monique,Graff, Micheline , p. 53 - 56 (1985) |
5.Export Top Purity 10-Hydroxy-2-decenoic acid 14113-05-4 In Stock
Handan Xindiya Chemicals Co. Ltd is a quality supplier of 10-Hydroxy-2-decenoic acid. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 10-Hydroxy-2-decenoic acid 14113-05-4.
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