L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-
Contact usL-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]- 1033804-86-2 with purity >99% Low price in stock
- Molecular Formula: C18H21ClN4O4
- Molecular Weight: 392.842
- PSA： 127.43000
- LogP: 3.87170
1033804-86-2 Relevant articles
Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome
Bednarz, Mark S.,Iimura, Shinya,Kanamarlapudi, Ramanaiah C.,Lim, Ngiap-Kie,Wu, Wenxue,Yan, Jie,Zhang, Haiming,Zhao, Matthew M.
, p. 261 - 273 (2020/03/10)
Two process routes for LX1031, a tryptop...
PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES
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Page/Page column 35, (2010/05/13)
Intermediates and synthetic processes fo...
SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL- 4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL) PROPANOIC ACID AND METHODS OF THEIR USE
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Page/Page column 9, (2009/04/24)
Solid forms of (S)-2-amino-3-(4-(2-amino...
Process for the preparation of substituted phenylalanines
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Page/Page column 16, (2009/03/07)
Intermediates and synthetic processes fo...
1033804-86-2 Process route
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216439-76-8
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
-
-
56-05-3
2-Amino-4,6-dichloropyrimidine
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![(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid](/upload/2026/6/4d32d0a214614f86870afdfff4173cd0_66f92de5-b0e0-41c5-85c3-9e1f9d1cdc10.png)
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1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
| Conditions | Yield |
|---|---|
|
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol;
for 0.333333h;
With
water; potassium hydrogencarbonate;
In
ethanol;
at 45 - 75 ℃;
With
citric acid;
In
water;
at 60 ℃;
for 2h;
pH=4.0;
Product distribution / selectivity;
|
84%
|
|
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine;
With
potassium carbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
methanol; ethanol; water;
at 80 ℃;
for 2h;
With
sodium hydroxide; water;
In
ethanol;
With
hydrogenchloride;
In
ethanol; water;
pH=3;
Product distribution / selectivity;
|
79%
|
|
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine;
With
potassium carbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol; water;
at 80 ℃;
for 2h;
With
hydrogenchloride; water;
pH=~ 3;
Product distribution / selectivity;
|
79%
|
|
With
potassium hydrogencarbonate;
POPd6;
In
ethanol; water;
at 75 ℃;
for 6h;
Product distribution / selectivity;
|
75%
|
|
With
palladium diacetate; potassium hydrogencarbonate; triphenylphosphine;
In
tetrahydrofuran; ethanol;
at 70 ℃;
for 20h;
Reagent/catalyst;
Solvent;
Temperature;
Catalytic behavior;
Inert atmosphere;
Large scale;
|
66%
|
|
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine;
With
potassium hydrogencarbonate;
palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; ethanol; water;
at 68 - 72 ℃;
for 20 - 23h;
Industry scale;
With
hydrogenchloride;
In
tetrahydrofuran; water; toluene;
pH=2.5 - 3.5;
Product distribution / selectivity;
Industry scale;
|
65%
|
|
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine;
With
potassium hydrogencarbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol; water;
at 75 - 80 ℃;
for 2h;
In
tetrahydrofuran; tert-butyl methyl ether;
pH=3.5;
Product distribution / selectivity;
Acidic conditions;
|
37%
|
|
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol; water;
at 65 - 80 ℃;
for 2 - 3h;
Product distribution / selectivity;
|
|
|
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine;
With
potassium hydrogencarbonate;
POPd6;
In
ethanol; water;
at 75 ℃;
for 6h;
With
hydrogenchloride;
In
tetrahydrofuran; water; toluene;
at 20 ℃;
pH=4.0;
Product distribution / selectivity;
|
75 %Spectr.
|
|
With
potassium hydrogencarbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol; water;
at 75 - 80 ℃;
for 2h;
Product distribution / selectivity;
|
-
-
56-05-3
2-Amino-4,6-dichloropyrimidine
-
-
1143525-81-8
(S)-2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid, lithium salt
-
-
1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
| Conditions | Yield |
|---|---|
|
With
potassium hydrogencarbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol; water;
at 70 ℃;
for 7h;
Product distribution / selectivity;
|
94%
|
|
With
potassium hydrogencarbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol;
at 70 ℃;
for 7h;
Product distribution / selectivity;
|
|
|
With
water; potassium hydrogencarbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
ethanol;
at 70 ℃;
for 7h;
|
1033804-86-2 Upstream products
-
56-05-3
2-Amino-4,6-dichloropyrimidine
-
119771-23-2
N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine
-
216439-76-8
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
-
1143525-81-8
(S)-2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid, lithium salt
1033804-86-2 Downstream products
-
1033804-87-3
(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid
-
1033805-09-2
(S)-2-amino-3-[4-(2-amino-6-{2,2,2-trifluoro-1-[5-methoxy-2-(4-methyl-pyrazol-1-yl)-phenyl]-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid
-
1033805-29-6
(S)-2-amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(2-thiazol-2-yl-phenyl)-ethoxy]-pyrimidin-4-yl}-phenyl)-propionic acid
-
1033805-86-5
(S)-3-[4-(2-amino-6-{2,2,2-trifluoro-1-[4-(6-methoxypyridin-2-yl)phenyl]ethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid
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