Memantine

Manufacturer supply top purity Memantine 19982-08-2 with ISO standards We supply high quality Memantine (CAS 19982-08-2), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Memantine ?

Memantine is White powder., while it's Molecular Formula is C12H21N. Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer''s disease and possibly vascular dementia (multi-infarct dementia). Memantine’s method of action involves an uncompetitive, low-affinity, open-channel blocker; it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission.

What is the CAS number for Memantine ?

The CAS number of Memantine is 19982-08-2.

More information of Memantine 19982-08-2 are:

Synonyms	1-Adamantanamine,3,5-dimethyl- (8CI);1,3-Dimethyl-5-aminoadamantane;1-Amino-3,5-dimethyladamantane;3,5-Dimethyl-1-adamantylamine;Alzantin;D 145;D 145 (sympathomimetic);DMAA;DRG 0267;Ebixa;
CAS?Number	19982-08-2
Molecular Formula	C12H21N
Molecular Weight	179.305
Density	1.046 g/cm³
Melting Point	153oC
Boiling Point	239.8 °C at 760 mmHg
Flash Point	92.3 °C
HS CODE	2921300090
PSA	26.02000
LogP	4.19640
Pka	10.79±0.60(Predicted)

What is Memantine (19982-08-2) used for?

Memantine is a potent antagonist of the N-methyl-D-aspartate (NMDA) receptor. Experimentally, memantine inhibits and reverses the abnor-mal activity of a protein phosphatase (PP-2A) that leads to tauhyperphosphorylation and to neurofibrillary degeneration inAD. Memantine is effective and well toler-ated in patients with severe AD and wasapproved by the FDA for the treatment of moderate-to-severe AD.

InChI:InChI=1/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;

Articles related to Memantine:

Article

Source

Synthesis, characterization, X-ray crystallography analysis and cell viability study of (η6-p-cymene)Ru(NH2R)X2 (X = Cl, Br) derivatives

McDarmont, Sarah L.,Jones, Meredith H.,McMillen, Colin D.,Smith, Everett Clinton,Pienkos, Jared A.,Joslin, Evan E.

, (2021)

Synthesis, crystallographic studies, molecular modeling and in vitro biological studies of silver(I) complexes with aminoadamantane ligands

dos Santos Pereira, Anna Karla,Nakahata, Douglas Hideki,Manzano, Carlos Marrote,de Alencar Simoni, Déborah,Pereira, Douglas Henrique,Lustri, Wilton Rogério,Formiga, André Luiz Barboza,Corbi, Pedro Paulo

, (2019)

How to get the best price on Memantine?

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